VARIKOZ KASALLIGI BO'LGAN HOMILADOR AYOLLARDA GEMOSTAZ O'ZGARISHLARINI ANIQLASH VA UNI KORREKSIYALASH
Keywords:
varikoz kasalligi, homiladorlik, gemostaz, giperkoagulyatsiya, trombotsitlar, tromboz, venoz tromboemboliya, past molekulyar vazndagi geparin, kompressiya terapiyasi, prenatal monitoring, koagulopatiya, fibrinoliz, perinatal asoratlar, venoz yetishmovchilik, prokoagulyant omillarAbstract
Ushbu ilmiy maqola varikoz kasalligi bilan og'rigan homilador ayollarda gemostaz tizimida yuzaga keladigan o'zgarishlarni chuqur tahlil qilishga bag'ishlangan. Tadqiqot davomida 120 nafar homilador ayol (varikoz kasalligi bor – 80 nafar, nazorat guruhi – 40 nafar) kuzatildi. Gemostaz ko'rsatkichlari – D–dimer, fibrinogen, protrombin vaqti (PT), aktivlashtirilgan qisman tromboplastin vaqti (AQTV), trombotsitlar soni – dinamikada o'rganildi.
Tadqiqot natijalari shuni ko'rsatdiki, varikoz kasalligi bilan og'rigan homilador ayollarda D–dimer darajasi nazorat guruhiga nisbatan 2,4 barobarga, fibrinogen esa 1,8 barobarga yuqori bo'lgan. Giperkoagulyatsiya holatlari 73,7% bemorida aniqlandi. Korreksiya sifatida past molekulyar vazndagi geparinlar (PMVG) va siquvchi kompressiya terapiyasi qo'llanilgan bo'lib, bu chora–tadbirlar trombotik asoratlar xavfini 68% ga kamaytirdi.
Xulosada, varikoz kasalligi bilan og'rigan homilador ayollarda gemostazni muntazam monitoring qilish va individual korreksiya rejimini belgilash perinatal asoratlarni sezilarli darajada kamaytirishga yordam beradi.
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