BACHADON BOYNI SARATONI MIKROBIOLOGIYASI
Keywords:
bachadaon boyni saratoni inson papillomavirus (HPV) HPV-16 HPV-18 Chlamydia trachomatis Mycoplasma genitalium mikrobiologik skrining onkologiya kolposkopiya servikal displaziyaAbstract
Maqsad: Ushbu tadqiqot bachadaon boyni saraton kasalligining rivojlanishida ishtirok etadigan mikrobiologik omillarni, jumladan inson papillomavirus (HPV), Chlamydia trachomatis, Mycoplasma genitalium va boshqa opportunistik mikroorganizmlarning klinik ahamiyatini kompleks baholashga qaratilgan.
Materiallar va metodlar: Tadqiqotga Respublika Onkologiya Markazining ginekologiya bo'limida 2021–2024 yillar davomida kuzatilgan 150 nafar bemorlar jalb etildi. Barcha bemorlarda PCR, bakteriologik ekish, kolposkopiya va gistologik tekshiruv metodlari qo'llanildi.
Natijalar: Tekshirilgan bemorlarning 85 nafari (56.7%) HPV-pozitiv bo'lib, ularning 75.3%ida HPV-16 va 21.2%ida HPV-18 turi aniqlandi. HPV-pozitiv bemorlarda Chlamydia trachomatis (49.4%), Mycoplasma genitalium (44.7%) va Herpes simplex virus-2 (34.1%) qo'shilish chastotasi statistik jihatdan sezilarli darajada yuqori ekanligi isbotlandi (p<0.05).
Xulosa: Bachadaon boyni saratonining rivojlanishida HPV bosh rol o'ynaydi, ammo qo'shimcha mikrobial infeksiyalar — ayniqsa C. trachomatis va M. genitalium — kasallikning og'irligini va prognozini yanada yomonlashtiradi. Kompleks mikrobiologik skrining dasturlarini joriy etish kliniko-profilaktik ahamiyat kasb etadi.
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