GENETIK OMILLAR VA TURMUSH TARZINING O‘ZARO TA’SIRI NATIJASIDA SUT BEZI SARATONI XAVFINING OSHISHI
Keywords:
sut bezi saratoni, genetik moyillik, BRCA, turmush tarzi, semizlik, gormonal omillar, gen-atrof-muhit o‘zaro ta’siri.Abstract
Ushbu maqolada sut bezi saratoni xavfining ortishida genetik moyillik va turmush tarzi omillarining o‘zaro ta’siri tahlil qilinadi. Maqsad gen-atrof-muhit o‘zaro ta’siri mexanizmlarini tizimlashtirishdir. Metod sifatida xalqaro va mintaqaviy manbalar bo‘yicha narrativ-sistematik tahlil qo‘llandi. Natijalar genetik risk yuqori bo‘lganda metabolik, reproduktiv va xulqiy omillar xavfni kuchaytirishini ko‘rsatadi.
References
1. King M.C., Marks J.H., Mandell J.B. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. New York, American Journal of Human Genetics, 2003. 164 p.
2. Mavaddat N., Michailidou K., Dennis J. et al. Polygenic risk scores for prediction of breast cancer and breast cancer subtypes. London, Nature Genetics, 2019. 17 p.
3. Esteller M. Epigenetics in cancer. New York, New England Journal of Medicine, 2008. 1148 p.
4. Wild C.P., Weiderpass E., Stewart B.W. World cancer report: cancer research for cancer prevention. Lyon, International Agency for Research on Cancer, 2020. 613 p.
5. Colditz G.A., Bohlke K. Priorities for the primary prevention of breast cancer. Philadelphia, CA: A Cancer Journal for Clinicians, 2014. 12 p.
6. McTiernan A. Physical activity in the prevention of breast cancer: current evidence and future directions. Oxford, British Journal of Sports Medicine, 2018. 9 p.
7. Seitz H.K., Stickel F. Molecular mechanisms of alcohol-mediated carcinogenesis. Berlin, Nature Reviews Cancer, 2007. 13 p.
8. Russo J., Russo I.H. The role of estrogen in the initiation of breast cancer. Boston, Journal of Steroid Biochemistry and Molecular Biology, 2006. 18 p.
9. Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ. Москва, РОНЦ им. Н.Н.Блохина РАМН, 2014. 226 с.
10. Ибрагимов Ш.Х., Мирзаев С.А. Онкология: клиника, диагностика ва профилактика. Тошкент, Абу Али ибн Сино номидаги тиббиёт нашриёти, 2018. 312 б.