COMPARATIVE EFFECTIVENESS OF DIFFERENT TOPICAL ANTIMICROBIAL AGENTS IN PREVENTING INFECTION IN ANORECTAL WOUNDS AFTER HEMORRHOIDECTOMY SURGERY
Keywords:
hemorrhoidectomy, anorectal wound, surgical site infection, topical antimicrobial, wound healing, chlorhexidineAbstract
This review explores the comparative effectiveness of various topical antimicrobial agents in preventing infections in anorectal wounds following hemorrhoidectomy surgery. The analysis encompasses a range of agents including bismuth subgallate-borneol compounds, metronidazole, ofloxacin combinations, mupirocin, gentamicin, and newer options like olanexidine and PHMB-containing solutions. Key findings suggest that chlorhexidine-alcohol significantly reduces surgical site infection (SSI) rates compared to povidone-iodine, while topical combinations with regenerative and analgesic properties enhance wound healing. Emerging agents such as antimicrobial hydrogels and polyhexanide-based solutions also show strong promise against resistant pathogens. The selection of appropriate antimicrobial therapy should consider the balance between microbial efficacy, wound healing potential, patient safety, and cost-effectiveness. This review underscores the importance of targeted topical strategies in postoperative anorectal care to optimize outcomes and reduce complications.
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