PREVENTING PURULENT COMPLICATIONS IN PEDIATRIC OSTEOMYELITIS (LITERATURE REVIEW)
Keywords:
Hematogenous osteomyelitis, pediatric infection, purulent complications, antibiotic therapy, diagnostic advancementsAbstract
Hematogenous osteomyelitis (HO) in children is a significant musculoskeletal infection, with purulent complications posing severe risks such as chronic infection, growth disturbances, and functional impairments. This review explores the pathogenesis, risk factors, diagnostic challenges, prevention strategies, and advancements in treatment to mitigate these complications. Timely diagnosis, appropriate antimicrobial therapy, and minimally invasive surgical techniques are essential to prevent long-term sequelae. Emerging diagnostic tools, including molecular and genomic methods, and innovative therapies such as hyperbaric oxygen therapy, highlight promising avenues for improving outcomes. A multidisciplinary approach remains critical for effective management and prevention.
References
1. A. Mamatov, K. Zhaparov, & N. Anarbaev. (2023). Effectiveness of Surgical Treatment Acute Hematogenic Osteomyelitis Children in the Complex With Ozone Therapy and Lymphogenic Technology. Бюллетень Науки и Практики. https://doi.org/10.33619/2414-2948/95/16
2. Acute bone and joint infections in children: Current concepts. (2022). Paediatrics and Child Health, 32(2), 57–63. https://doi.org/10.1016/j.paed.2021.11.003
3. Adriana Sarmiento Clemente, J. Chase McNeil, Kristina G. Hulten, Jesus G. Vallejo, Michael E Scheurer, & Sheldon L. Kaplan. (2023). Assessing risk for complications in acute hematogenous osteomyelitis in children. Validation of two predictive scores. Journal of the Pediatric Infectious Diseases Society. https://doi.org/10.1093/jpids/piad095
4. Adriana Sarmiento Clemente, J. Chase McNeil, Kristina G. Hulten, Jesus G. Vallejo, & Sheldon L. Kaplan. (2022). 1333. Prognostic Factors Associated with Complications of Acute Hematogenous Osteomyelitis in Children. Open Forum Infectious Diseases, 9(Supplement_2). https://doi.org/10.1093/ofid/ofac492.1163
5. Ahmed Al‐Alawi, Sameer Raniga, Ian C. Michelow, Laila Al-Yazidi, & Zaid Alhinai. (2024). Early Bone Ischemia in Pediatric Acute Hematogenous Osteomyelitis and its Association With Progression to Chronic Osteomyelitis: New Insights From Gadolinium-enhanced Subtraction MRI. Pediatric Infectious Disease Journal. https://doi.org/10.1097/inf.0000000000004552
6. Alina Shchepetkina & m0sukon974. (2023). Early crp trends in childhood osteomyelitis predict complicated disease. Orthopaedic Proceedings, 105-B(SUPP_3), 73–73. https://doi.org/10.1302/1358-992x.2023.3.073
7. Andrea Yeo & Manoj Ramachandran. (2014). Acute haematogenous osteomyelitis in children. BMJ, 348. https://doi.org/10.1136/BMJ.G66
8. Andrew M. McDonald, Lesley Voss, Matthew J. Boyle, & Haemish Crawford. (2023). An Update on Pediatric Acute Hematogenous Osteomyelitis in New Zealand—A Decade on. https://doi.org/10.1097/BPO.0000000000002443
9. Shuxrat o‘g‘li P. S. EEG CHARACTERISTICS OF DIFFERENT TYPES OF FOCAL EPILEPSY IN ADULT PATIENTS //Web of Medicine: Journal of Medicine, Practice and Nursing. – 2023. – Т. 1. – №. 9. – С. 1-3.
10. UNDERSTANDING AND MANAGING CONSTIPATION IN CHILDREN AGED 0-3: CAUSES, DIAGNOSIS, AND TREATMENT STRATEGIES. (2025). ORIENTAL JOURNAL OF MEDICINE AND NATURAL SCIENCES, 2(1), 4-12. https://innoworld.net/index.php/ojmns/article/view/206
11. Жураев, С. Б. ОПТИМИЗАЦИЯ ТАКТИКИ ХИРУРГИЧЕСКОГО ЛЕЧЕНИЯ ПОВРЕЖДЕНИЙ АРТЕРИЙ КОНЕЧНОСТЕЙ ПРИ СОЧЕТАННЫХ ТРАВМАХ. «YOSH OLIMLAR TIBBIYOT JURNALI» TASHKENT MEDICAL ACADEMY «MEDICAL JOURNAL OF YOUNG SCIENTISTS» ТАШКЕНТСКАЯ МЕДИЦИНСКАЯ АКАДЕМИЯ, 82.
12. Jurayev S.B. (2024). CURRENT TREATMENT OPTIONS OF ADHESIVE SMALL BOWEL OBSTRUCTION (LITERATURE REVIEW). https://doi.org/10.5281/zenodo.14506496
13. Abdurakhmonov, N. (2024). THE IMPORTANCE OF DIFFERENTIAL DIAGNOSING IN TREATMENT OF MARGINAL BLEPHARITIS WITH DEMODEX ETIOLOGY. Science and innovation, 3(D5), 188-192.
14. O’Gli P. S. S. KATTA YOSHLI BEMORLARDA FOKAL EPILEPSIYANI TURLI XILLIGINI EEG XUSUSIYATLARI //Ta’lim fidoyilari. – 2022. – Т. 5. – №. 9. – С. 621-624.
15. Tashmamatova , D. (2025). TIBBIYOT TALABLARINI PEDİATRIYA FANLARINI O’QITIShNI BAHOLASH: SHARH MAQOLA. Universal Xalqaro Ilmiy Jurnal, 2(1), 68–75. Retrieved from https://universaljurnal.uz/index.php/jurnal/article/view/1402
16. Niyozbek Abdurakhmonov Khamdamjon Ogli, & Gulomov Qahhorali (2024). IMPROVEMENT OF SURGICAL TACTICS AND TREATMENT OF COMBINED INJURIES IN CHILDREN. Eurasian Journal of Medical and Natural Sciences, 4 (5-2), 17-21. doi: 10.5281/zenodo.11367251
17. Пирматов Ш.Ш., Рахматуллаева Н.И., & Холматов Р.И. (2021). ОСОБЕННОСТИ ЭЭГ РАЗЛИЧНЫХ ТИПОВ ФОКАЛЬНОЙ ЭПИЛЕПСИИ У ВЗРОСЛЫХ ПАЦИЕНТОВ. Экономика и социум, (10 (89)), 964-971.
18. Tashmamatova D.K. (2024). NOVEL APPROACHES TO ENHANCE BACHELOR'S DEGREE OF MEDICAL EDUCATION (LITERATURE REVIEW). https://doi.org/10.5281/zenodo.14220190
Qurbonbek o’g’li, D. S. (2023). THE RELATIONSHIP BETWEEN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND CARDIOVASCULAR DISEASE (CVD). PEDAGOG, 6(12), 85-96.