EARLY IDENTIFICATION OF OVARIAN FUNCTIONAL DECLINE AND CONTEMPORARY APPROACHES TO CLINICAL MANAGEMENT
Keywords:
ovarian insufficiency, ovarian reserve, early diagnosis, hormonal biomarkers, reproductive endocrinology, fertility preservation, hormone therapyAbstract
Premature impairment of ovarian function represents a critical gynecological and endocrinological challenge with profound reproductive and systemic consequences. Declining ovarian reserve before the age of natural menopause disrupts fertility potential, endocrine balance, and long-term metabolic health. Timely recognition of ovarian functional decline is essential to prevent irreversible infertility, skeletal demineralization, and cardiovascular morbidity. This comparative observational study evaluated early diagnostic indicators and management perspectives of ovarian insufficiency by analyzing clinical manifestations, hormonal parameters, and ultrasonographic markers. A total of 56 women were enrolled, including 28 patients with ovarian insufficiency and 28 age-matched healthy controls examined at the Fergana District Medical Association. Significant alterations were observed in gonadotropin concentrations, estradiol levels, anti-Müllerian hormone values, ovarian volume, and antral follicle count among affected patients.
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